Yuhui Wang, Zhong‐Yan Cao, Jian Zhou
Aug 18, 2016
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0
Influential Citations
22
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Journal
The Journal of organic chemistry
Abstract
We report a general difluoromethylenation of various types of ketones using diethyl (difluoro(trimethylsilyl)methyl)phosphonate mediated by the combination of 18-crown-6 and KOAc. It provides facile access to structurally diverse β-hydroxy-α,α-difluorophosphonates as interesting targets for medicinal research.