Roman M. Bychek, Valeriia Hutskalova, Yuliya P. Bas
Sep 25, 2019
Citations
1
Influential Citations
48
Citations
Journal
The Journal of organic chemistry
Abstract
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by CF3TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are suggested as saturated bioisosteres of the benzene ring for drug discovery projects.