M. Shibakami, M. Inagaki, S. Regen
Dec 17, 1997
Citations
0
Influential Citations
2
Citations
Journal
Journal of the American Chemical Society
Abstract
The influence of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC) on the mixing behavior of phospholipids derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) has been examined in the fluid bilayer state by means of nearest-neighbor recognition methods (Davidson, S. K. M.; Regen, S. L. Chem. Rev. 1997, 97, 1269). When disulfide-based dimers derived from DMPE and DSPE were allowed to undergo monomer exchange at 60 °C, in the presence of 50 mol % of DPPC, an equilibrium molar ratio of heterodimer to each homodimer was found to be 1.95 ± 0.07; with DMPC as the diluent, a small but significant level of nearest-neighbor recognition was observed (i.e., the dimer ratio was 1.86 ± 0.02). In sharp contrast, the use of DLPC resulted in a very strong demixing effect, which was characterized by a dimer ratio of 0.88 ± 0.04. The mechanist...