K. R. Rowan, E. M. Holt
Jun 15, 1996
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Influential Citations
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Journal
Acta Crystallographica Section C-crystal Structure Communications
Abstract
The crystal structure of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C 19 H 22 N 2 O 6 (FR7534), a member of the 1,4-dihydropyridine class of calcium blockers, and the crystal structures of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate, C 19 H 20 N 2 O 6 , and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C 17 H 16 N 2 O 6 , decomposition products of FR7534 and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-pyridine-3,5-dicarboxylate, respectively, reveal that the decomposition products display conformational features associated with activity according to structure-activity relationships.