R. Kelly
1969
Citations
0
Influential Citations
20
Citations
Journal
Journal of chromatography
Abstract
Abstract Dimethyldiacetoxysilane is a convenient reagent for thermal stabilisation of suitable corticosteroids to give siliconides with good gas chromatographic properties. The conversion to the derivative is high and the simplicity and speed of the procedure allows rapid analysis of corticosteroid mixtures. The technique is applicable to steroids with the 17α, 21-dihydroxy-20-oxo side chian, but not to such steroids as corticosterone where siliconide formation is not possible. Steroids with unhindered hydroxyl groups form thermally stable silyl derivatives with this reagent.