M. Lautens, E. Tayama, D. Nguyen
Jan 8, 2004
Citations
0
Influential Citations
23
Citations
Journal
Organic letters
Abstract
[reaction: see text] The first synthetic application of 2-methyl-2-vinyloxirane as a masked dienolate has been successfully demonstrated in the direct vinylogous Mannich-type reaction with an alpha-imino ester as an electrophile. The Mannich adduct was a useful intermediate en route to cis-5-substituted pipecolinic acid ethyl ester under simple hydrogenation conditions.