Mao Xuan, Chunlei Lu, Meina Liu
May 29, 2019
Citations
0
Influential Citations
14
Citations
Journal
The Journal of organic chemistry
Abstract
Direct thioesterification of carboxylic acids with thiols using nontoxic activation agents is highly desirable. Herein, an efficient and practical protocol using safe and inexpensive industrial waste polymethylhydrosiloxane as the activation agent and K3PO4 with 18-crown-6 as a catalyst is described. Various functional groups on carboxylic acid and thiol substituents can be tolerated by the present system to afford thioesters in yields of 19-100%.