D. Reitz, S. M. Massey
Feb 1, 1990
Citations
0
Influential Citations
24
Citations
Journal
Journal of Organic Chemistry
Abstract
N-tert-Butyl-N-methyl-2-methoxybenzamide (11) undergoes directed metalation and reaction with methyl iodide to provide N-tert-butyl-N-methyl-2-methoxy-6-methylbenzamide (10) in 98% yield. The potential synthetic usefulness of N-tert-butyl-N-methylbenzamides in directed metalation syntheses was further demonstrated by the synthesis of lunularic acid (12) in 51% overall yield from 11