Tihamér A. Paál, Arto Liljeblad, L. Kanerva
Nov 1, 2008
Citations
1
Influential Citations
20
Citations
Journal
European Journal of Organic Chemistry
Abstract
The first synthesis of both enantiomers of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B- or subtilisin Carlsberg-catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH4OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92–93 % ee) in good yields (85–92 %). (R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid was obtained with high enantiopurity (98 % ee) and in good yield (85 %) in a CAL-B-catalysed process, under similar conditions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)