N. Nedolya, L. Brandsma, B. Trofimov
Sep 1, 1997
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Reaction of methyl isothiocyanate with two equivalents of lithium diisopropylamide, followed by alkylation with dimethyl sulfate gives 2-methyl-5-N,N-dimethylaminothiazole in a high yield. The isomer, 1-methyl-2,5-bis(methylthio)imidazole is obtained in a high yield, if prior to methylation, the reaction mixture is stirred for some period with water at room temperature. © 1997 Elsevier Science Ltd.