F. Faigl, Katalin Fogassy, Z. Szántó
Apr 23, 1998
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron
Abstract
Abstract Lithiation of 1-(fluorophenyl)pyrroles occurred exclusively ortho to the fluorine substituent independently of the structure of the tertiary amine type ligands used. Semiempirical quantum chemical calculations confirmed that the special directing effect of fluorine atom is manifested by increasing kinetic acidity of the neighbouring position while the α hydrogens of the pyrrole rings are the most acidic in ground state.