Takuya Washio, Seiichi Nakamura, M. Anada
Dec 31, 2005
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Influential Citations
6
Citations
Journal
Heterocycles
Abstract
A first example of chiral dirhodium(II) complex-catalyzed enantioselective Mukaiyama aldol reactions is described. The aldol addition reaction of methyl acetate-derived trimethylsilylketene acetal with specific aldehydes such as benzyloxyacetaldehyde and electron-poor aromatic aldehydes is effectively catalyzed by dirhodium(II) tetrakis[N-benzene-fused phthaloyl-(S)-piperidinonatel (la), providing silylated aldol adducts in up to 94% ee.