L. Chan, S. Das, T. Reddy
Feb 9, 2004
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Influential Citations
115
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Further SAR studies on the thiophene-2-carboxylic acids are reported. These studies led to the identification of a series of tertiary amides that show inhibition of both HCV NS5B polymerase in vitro and HCV subgenomic RNA replication in Huh-7 cells. Structural insights about the bioactive conformation of this class of molecules were deduced from a combination of modeling and transferred NOE (trNOE) studies.