J. Levin, J. M. Chen, M. Du
Nov 19, 2001
Citations
0
Influential Citations
31
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.