T. Sakamoto, Y. Koga, Masataka Hikota
Dec 1, 2014
Citations
0
Influential Citations
22
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30=2.1 nM) and a high isozyme selectivity.