K. Nicolaou, M. Zak, S. Rahimipour
Oct 6, 2005
Citations
0
Influential Citations
65
Citations
Journal
Journal of the American Chemical Society
Abstract
Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as cytotoxic action against a number of cancer cell lines.