Jinho Lee, Kyoung-Hee Kim, Shinwu Jeong
Jul 15, 2011
Citations
0
Influential Citations
29
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.