M. Gustafsson, Jacob Jensen, S. M. Bertozzi
Oct 1, 2010
Citations
0
Influential Citations
8
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) release in rats, consistent with its profile as a PAM of CaSRs.