Jon L. Wright, T. Gregory, T. Heffner
Jun 3, 1997
Citations
0
Influential Citations
29
Citations
Quality indicators
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract High volume screening identified 3-(4-benzylpiperidinyl)-1-naphthoxy-2-propanol as a selective dopamine D4 receptor ligand. A systematic structure-activity study revealed that the benzyl group could be replaced with phenoxy and the naphthalene with phenyl to improve potency almost tenfold. The (R) enantiomer of this compound had a D4 affinity of 2 nM and was over 100-fold weaker at dopamine D2 and D3 receptors.