M. Furber, L. Alcaraz, C. Luckhurst
Dec 15, 2012
Citations
0
Influential Citations
3
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metabolism and leading to the identification of compound 60 with a greatly improved in vivo pharmacokinetic profile.