J. Hwang, David C. Smithson, M. Connelly
2010
Citations
0
Influential Citations
9
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.