H. Pingali, Mukul R Jain, Shailesh R. Shah
Oct 15, 2008
Citations
0
Influential Citations
12
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid 13c exhibited potent hypoglycemic and lipid lowering activity with high oral bioavailability in animal models.