E. Parmee, H. Ok, M. Candelore
May 5, 1998
Citations
1
Influential Citations
35
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A study of 4-acylaminobenzenesulfonamides in a cloned human β 3 adrenergic receptor assay resulted in the discovery of n -hexylurea, L-755,507 ( 22 ). This 0.43 nM β 3 agonist, which is >440-fold selective over both β 1 and β 2 binding, is among the most potent human β 3 agonists reported to date.