J. Wright, T. Gregory, P. Boxer
Oct 4, 1999
Citations
0
Influential Citations
16
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
4-Benzyl-1-[4-(1H-imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent antagonist of the NR1A/2B subtype of the NMDA receptor. When dosed orally, this compound potentiates the effects of L-DOPA in the 6-hydroxydopamine-lesioned rat, a model of Parkinson's disease.