H. Zeng, David B. Belanger, Patrick J. Curran
Oct 1, 2011
Citations
0
Influential Citations
30
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.