J. Zhang, An‐Rong Li, Ming Yu
Jun 15, 2013
Citations
0
Influential Citations
16
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We describe the discovery of a series of arylsulfonyl 3-(pyridin-2-yloxy)anilines as GPR119 agonists derived from compound 1. Replacement of the three methyl groups in 1 with metabolically stable moieties led to the identification of compound 34, a potent and efficacious GPR119 agonist with improved pharmacokinetic (PK) properties.