W. Cheung, R. Calvo, B. Tounge
Aug 15, 2008
Citations
0
Influential Citations
17
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of piperidine carboxamides were developed as potent antagonists of the transient receptor potential vanilloid-1 (TRPV1), an emerging target for the treatment of pain. A focused library of polar head groups led to the identification of a benzoxazinone amide that afforded good potency in cell-based assays. Synthesis and a QSAR model will be presented.