Zhijian Zhao, W. Leister, J. O'brien
Mar 1, 2009
Citations
0
Influential Citations
20
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Employing an iterative analogue library approach, novel potent and selective glycine transporter 1 (GlyT1) inhibitors containing a 4-pyridin-2-ylpiperidine sulfonamide have been discovered. These inhibitors are devoid of time-dependent CYP inhibition activity and exhibit improved aqueous solubility versus the corresponding 4-phenylpiperidine analogues.