Jian Liang, J. Canary
Oct 11, 2010
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Influential Citations
36
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Angewandte Chemie
Abstract
Manganese is an essential metal in all forms of life.[1] It participates as a co-factor in diverse classes of enzymes and the photosynthetic machinery[2] and is used widely as a versatile tool for biological studies. For example, high spin Mn 2+ is an excellent MRI relaxation agent that has been used in clinical diagnosis and is of widespread interest as a tool in neurobiological research.[3] However, chronic over-exposure can result in movement disorders and mental disturbances and other brain-related toxicities.[4] Fluorescent probes would be useful for detection and quantification of Mn 2+ , as this method offers high efficiency, high sensitivity and easy operation[5] among available methods of detection.[6] However, development of an effective fluorescent probe for Mn 2+ faces several challenges: