Brian Mead, L. H. Patterson, Dennis A. Smith
Sep 1, 1981
Citations
0
Influential Citations
13
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
FPL 55712 (7-13-(4-acetyl-3-hydroxy-2-propyl-phenoxyl2-hydroxypropoxyl-4-0x0-8 propyl-4H-benzopyran-2 carboxylic acid I), has been widely referred to since its discovery as a selective antagonist of SRS-A (Augstein et al 1973) and the literature has been reviewed (Chand 1979). However, there are no reports describing the disposition or pharmacokinetics of the compound. The results of experiments conducted in the rat and dog as part of a limited programme of preclinical safety studies are therefore described here.