H. Mcilhenny, S. Levine, E. H. Wiseman
Jan 1, 1978
Citations
0
Influential Citations
3
Citations
Journal
Experimental Neurology
Abstract
Abstract The nonacidic, nonsteroidal, anti-inflammatory agent, flumizole, penetrates the central nervous system of rats following oral drug administration, reaching concentrations in brain and spinal cord which are several-fold higher than plasma concentrations. Maximum drug concentrations in brain and plasma are achieved simultaneously and decay with similar half-lives (8 h). The drug is well absorbed orally and is excreted primarily with feces after biliary secretion. The distribution and elimination of flumizole is comparable in normal rats and in rats afflicted with experimental allergic encephalomyelitis; the drug is not selectively concentrated at either peripheral or central nervous system sites of inflammation. Flumizole is inactive in the rat model of the disorder under conditions that demonstrate therapeutic success with myelin basic protein.