E. Kvaratskhelia, R. Kvaratskhelia, R. Kurtanidze
Apr 2, 2013
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Abstract
Cyclopentanedicarboxylic acids are widely used in industry as pharmaceutical intermediates. Their useful properties are closely connected with the peculiarities of their behaviour in solutions and, consequently, with the regularities of their electrolytic dissociation which determine the distribution of biopharmaceutically active and inactive forms in their solutions. In this communication the analysis of the complex equilibria in the processes of electrolytic dissociation of isomeric cis and trans-1,2-cyclopentanedicarboxylic acids is carried out with the aid of original method suggested by authors for case of weak multibasic organic acids. For weak dibasic organic acids the law of dilution for both dissociation steps may be expressed as follows: