Huang Mutong, Tcm Resources
2012
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Journal
China Modern Medicine
Abstract
Objective To develop a method for dissolution determination of mitiglinide calcium hydrate dispersible tablets.Methods The dissolution was determined with paddle method (50 r/min) in 900 mL water.Mitiglinide calcium was detected by high performance liquid chromatography (HPLC).Results There was a good linearity over the range of 7.15 to 11.55 μg/mL with a correlation coefficient r=0.999 9.And average recovery was 100.03%.Conclusion The method is simple,accurate,reliable and the quality of the mitiglinide calcium hydrate dispersible tablets can be well controlled by this method.