K. Ishiwata, S. Ishii, Toru Sasaki
Apr 1, 1993
Citations
0
Influential Citations
19
Citations
Journal
Applied Radiation and Isotopes
Abstract
Abstract A semi-automated synthesis of [1- 11 C]acetate for routine clinical studies by positron emission tomography is described. Carboxylation of methylmagnesium chloride in THF with [ 11 C]CO 2 followed by the HCl hydrolysis at low temperature gave [1- 11 C]acetic acid, which was distilled with a N 2 flow into a NaHCO 3 solution. After radioactive and nonradioactive undesirable products were removed by evaporation of the solution to dryness, a sterile and apyrogenic [1- 11 C]acetate injection was obtained within 20 min.