A. By, B. Dawson, B. Lodge
Sep 1, 1989
Citations
0
Influential Citations
5
Citations
Journal
Forensic Science International
Abstract
The recent identification of the anorectic agent 4-methylaminorex (2-amino-4-methyl-5-phenyl-2-oxazoline) as a police exhibit in Canada led to the need to synthesize a reference standard specimen. Since this substance can occur as cis- and trans- isomers, both had to be prepared and characterized spectrally. Cis-methylaminorex was made from the erythro amino alcohol norephedrine (phenylpropanolamine), while the trans compound was made from the threo diastereoisomer norpseudoephedrine, in both cases by the treatment of the substrate with cyanogen bromide in a methanolic solution of sodium acetate. In this paper, the 13C- and 1H-NMR, infrared (IR), mass (MS) and ultraviolet (UV) spectra are reported, together with a commentary on the distinguishing features noted between the sets of spectra.