S. Symchowicz, W. Peckham, M. Eisler
Jun 1, 1962
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
Biochemical Pharmacology
Abstract
S/sup 35/-perphenazine of high specific activity was synthesized, and the identity and radiochemical purity of the product were established. Tissue distribution and excretion of radioactivity were studied in rats after subcutaneous injection of 0.3 mg of S/sup 35/-labeled perphenazine dihydrochloride/kg body weight. Maximal concentrations of radioactivity were found in most tissues after 1 hr. Tissues showing the highest peak concentrations were lung, adrenal, liver, kidney, spleen, and pituitary, while the brain parts had somewhat lower, but appreciable, amounts. Blood levels were consistently low. High levels of radioactivity were found in the pituitary gland after 48 hr and remained relatively high even after 6 days. Over 80 per cent of the drug was excreted during a period of 24 hr; most of this (80 per cent) was excreted in the feces, while only 20 per cent could be found in the urine. Experiments performed with female rats in day 19 of pregnancy showed small amounts of radioactivity crossing the placenta. After 24 hr, however, the concentration of radioactivity in the fetus and amniotic fluid was extremely low. (auth)