H. M. Solomon, F. J. Figge
Mar 1, 1959
Citations
0
Influential Citations
31
Citations
Quality indicators
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary Oral administration of collidine derivative (Diethyl 1, 4-dihydro-2, 4, 6-tri-methylpyridine-3, 5-dicarboxylate) to mice produces a disturbance in porphyrin metabolism characterized by marked increases in hepatic proto- and coproporphyrin. Red fluorescence of kidneys of animals treated with this agent for 7 days is associated with great increase in renal protoporphyrin and smaller increase in renal uroporphyrin. In the guinea pig, oral administration of collidine derivative produced high levels of urinary copropor-phyrin and trace amounts of urinary porphobilinogen.