K. Lindros, A. Stowell, P. Pikkarainen
Sep 1, 1981
Citations
1
Influential Citations
64
Citations
Journal
Alcoholism, clinical and experimental research
Abstract
4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.