H. Goldman, C. Scriver, K. Aaron
Apr 18, 1970
Citations
2
Influential Citations
46
Citations
Quality indicators
Journal
Lancet
Abstract
Abstract Dithiothreitol (D.T.T.) removes cystine from cystinotic fibroblasts. The reagent is not toxic to cells at low concentrations (0.1 m M ). A cystinotic patient tolerated D.T.T. intravenously for 10 days with apparent reduction of cystine storage in rectal mucosa. He died of uraemia 1 month later.