Dian-yu Liu, Guowei Zhao, Lan Xiang
Jul 1, 2010
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0
Influential Citations
153
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Quality indicators
Journal
European Journal of Organic Chemistry
Abstract
Because indoline is an important intermediate of angiotensin-converting enzyme (ACE) inhibitor and the antihypertensive drug "pentopril", and also because it is a ubiquitous scaffold found in the structures of several naturally bioactive alkaloids such as vinblastine, strychnine, (-)-physostigmine, ajmaline, and (+)-aspidospermidine, the synthesis of this "privileged structure" is meaningful in the design of new biologically active medicines. This microreview describes the recent advances in the synthesis of indoline derivatives, including Cu- and Pd-catalyzed reactions, metal-free approaches (radical reaction), as well as other types of reactions.