L. Robbiano, G. Gazzaniga, A. Martelli
Mar 1, 1986
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Mutation research
Abstract
The genotoxicity of tripelennamine, an antihistamine used in the treatment of allergic disorders, was examined in human hepatocyte primary cultures derived from 3 different donors, after exposure to non-toxic concentrations ranging from 10 to 100 microM. A modest but statistically significant and dose-related amount of autoradiographic DNA repair was present in cultures from two donors. DNA fragmentation, as measured by alkaline elution, was found to occur in dose-dependent amounts in cultures of all the 3 donors. These findings, which agree with the previously observed capability of tripelennamine to induce DNA repair and fragmentation in rat hepatocytes, strengthen the suspicion of a potential genotoxic risk of this drug to humans.