L. Zaske, M. Perrin, F. Leveiller
Dec 1, 2001
Citations
0
Influential Citations
24
Citations
Journal
Journal De Physique Iv
Abstract
Docetaxel, a stoichiometric hydrate containing three water molecules per molecule of drug substance, is thermodynamically stable under ambient conditions of pressure, temperature and relative humidity. Dehydration of this form was subjected to X-ray powder diffraction (XRPD) and thermogravimetric experiments. To obtain a better understanding of the observed structural changes between trihydrate and dehydrated forms, the crystalline structure of docetaxel was refined using high resolution XRPD data coupled with an ab initio direct space method.