S. Thilagam, S. Rajendran
2015
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Quality indicators
Journal
Paripex Indian Journal Of Research
Abstract
The Naphthyridine family seeks an attention due to its antibacterial and anticancer properties.In present study the effect of 9-methoxy benzo[b][1,8] Naphthyridin-2(1H)-one has been synthesized and tested for its potential anticancer property against lung cancer . The proteins ALK, EGFR, KRAS , RET and ROSI which are responsible for causing lung cancer , the compound has shown strong binding property against the proteins , tested in docking analysis in which RET protein had showed highest activity with reference to the results obtained through Insilico analysis .Invitro antitumor activity has been investigated using A549 cell line.The result shown that the compound has produced maximum cell death of about 75%. Hence with the results of the study, 9-methoxy benzo[b][1,8] Naphthyridin-2(1H)-one has shown to have a considerable property against lung cancer.These findings suggest that 1,8-naphthyridine derivatives are a promising class of compounds in cancer research.