L. Palenzuela, N. Hahn, R. Nelson
Jun 15, 2005
Citations
5
Influential Citations
121
Citations
Quality indicators
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Abstract
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.