C. Enguehard-Gueiffier, Pierre‐Olivier Delaye, M. Pénichon
Sep 11, 2015
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Influential Citations
3
Citations
Journal
Synthesis
Abstract
Abstract A regiocontrolled 6-endo-dig cyclization of 3-ethynylimidazo[1,2-a]pyridine-2-carbonitriles promoted by Grignard reagent in the presence of iodine has been developed. We optimized the reaction conditions to allow the straightforward synthesis of 1,3-disubstituted 4-iodoimidazo[1,2-a:4,5-c′]dipyridines. Finally, the reactivity of the 4-iodo position toward various metal-catalyzed coupling reactions (Suzuki–Miyaura, Sonogashira, etc.) or cyanation was successfully evaluated.