C. Matassini, S. Mirabella, A. Goti
Jul 1, 2012
Citations
0
Influential Citations
32
Citations
Journal
European Journal of Organic Chemistry
Abstract
A D-mannose-derived aldehyde with the D-lyxo configuration is a versatile key intermediate to functionally and stereochemically diversified piperidines. It allowed the synthesis of natural 3,4,5-trihydroxypiperidines and new analogs through a double reductive amination strategy and the synthesis of novel 2-cyanotrihydroxypiperidines through a highly regio- and diastereoselective Strecker reaction.