H. Kim, B. Son, Boyi Song
Jun 1, 2005
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Journal
Heterocycles
Abstract
syn,syn-Bis(1,2-isoxazolin-5-yl)methanols and syn,syn,syn-1,2-bis(1,2-isoxazol-5-yl)ethane-1,2-diols were synthesized from various nitrile oxides with 1,4-pentadien-3-ol and 1,5-hexadiene-3,4-diol respectively in the presence of ethylmagnesium bromide by double diastereoselective 1,3-dipolar cycloaddition reaction. The resulting isoxazolines were converted to the corresponding new polyols by hydrogenolysis with Raney Ni.