K. David Hay, H. Konrad Muller, Peter C. Reade
Mar 1, 1978
Citations
0
Influential Citations
25
Citations
Quality indicators
Journal
Oral surgery, oral medicine, and oral pathology
Abstract
Penicillamine (beta1 beta2 dimethylcysteine) is the drug of choice in the therapeutic management of Wilson's disease and cystinuria and has been used in the treatment of some heavy-metal intoxications. Recent studies have shown that it is efficacious in patients with rheumatoid arthritis. Side effects include sensitivity reactions, nephrotoxicity, bone-marrow suppression, hypogeusia, skin lesions, and the formation of autoantibodies. Two cases are described with the features of pemphigus which were attributed to penicillamine therapy.