Navasona Krishnan, C. Felice, Keith D. Rivera
Jun 26, 2018
Citations
1
Influential Citations
30
Citations
Journal
Genes & Development
Abstract
In this study, Krishnan et al. present the characterization of DPM-1001 as a potent and highly selective chelator of copper that is orally bioavailable. Treatment of the toxic milk mouse model of Wilson's disease with DPM-1001 lowered the levels of copper in the liver and brain, removing excess copper by excretion in the feces while ameliorating symptoms associated with the disease, suggesting that DPM-1001 should be investigated further as a new therapeutic agent for the treatment of Wilson's disease.