K. J. Andrews, F. Bultitude, E. Evans
1962
Citations
0
Influential Citations
16
Citations
Journal
Journal of The Chemical Society (resumed)
Abstract
2-Methyl-6-tritio-1,4-naphthaquinol bis (disodium phos phate) was prepared by reductive dehalogenation of the corresponding 6-iodo-compound by carrier-free tritium. The product, of specific activity 27 curies per millimole, remained essentially radiochemically pure in aqueous solution for several months. Preliminary laboratory and clinical investigations of the compound as a new form of treatment of human malignancies suggested the need for even higher activity. 5,6,7-Tribromo-2-methyl-1,4-naphthaquinol bis(disodium phosphate) was therefore synthesized and likewise reduced to the tritritio-compound of specific activity 83 curies per millimole. (auth)